Rheumatoid arthritis RNA Ribonucleic acid RPE Retinal pigment epithelium SARS Severe acute respiratory syndrome SLE Systemic lupus erythematosus TLR Toll-like receptor TNF Tumor necrosis factor
ثبت نشده
چکیده
4AQR 4-Aminoquinoline retinopathy 4AQs 4-Aminoquinolines (chloroquine and hydroxychloroquine) ABW Actual body weight APC Antigen presenting cell BCVA Best corrected visual acuity C Chloroquine C p G ODN C p G oligodeoxynucleotide CV Color vision CYP Cytochrome P450 enzymes DFE Dilated fundus examination DNA Deoxyribonucleic acid ERK Extracellular signal-regulated kinases FP Ferriprotoporphyrin IX GVF Goldmann visual fi elds HC Hydroxychloroquine HIV Human immunodefi ciency virus HMG-CoA 3-Hydroxy-3-methylglutarylcoenzyme A reductase IBW Ideal body weight IFN Interferon IL Interleukin LD 50 Lethal dose 50 LDL Low-density lipoprotein M Mole mRNA Mitochondrial ribonucleic acid NG Not given RA Rheumatoid arthritis RNA Ribonucleic acid RPE Retinal pigment epithelium SARS Severe acute respiratory syndrome SLE Systemic lupus erythematosus TLR Toll-like receptor TNF Tumor necrosis factor TNF-α Tumor necrosis factor α V Volume of distribution
منابع مشابه
Rheumatoid arthritis RNA Ribonucleic acid RPE Retinal pigment epithelium SARS Severe acute respiratory syndrome SLE Systemic lupus erythematosus TLR Toll-like receptor TNF Tumor necrosis factor
4AQR 4-Aminoquinoline retinopathy 4AQs 4-Aminoquinolines (chloroquine and hydroxychloroquine) ABW Actual body weight APC Antigen presenting cell BCVA Best corrected visual acuity C Chloroquine C p G ODN C p G oligodeoxynucleotide CV Color vision CYP Cytochrome P450 enzymes DFE Dilated fundus examination DNA Deoxyribonucleic acid ERK Extracellular signal-regulated kinases FP Ferriprotoporphyrin ...
متن کاملAre Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation,...
متن کامل[The role of BAFF in autoimmune diseases].
B cell activating factor belonging to the tumor necrosis factor family (BAFF) is a tumor necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF is a ligand for three TNF receptor superfamily members: B-cell maturation antigen (BCMA), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), and BAFF receptor...
متن کاملHydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus
INTRODUCTION Plasmacytoid dendritic cells (pDCs) constitutively express two members of the Toll-like receptor (TLR) family, TLR-9 and TLR-7, through which they can be stimulated to produce high levels of interferon (IFN)-α, a key mediator of the pathogenesis of systemic lupus erythematosus (SLE). Given the known efficacy of hydroxychloroquine (HCQ) in the treatment of SLE, we examined its abili...
متن کاملEtanercept-induced pleuropericardial lupus-like syndrome.
Tumour necrosis factor (TNF)-a is currently being targeted in autoimmune joint diseases, including rheumatoid arthritis (RA) and spondylarthropathies [1, 2]. Widespread use of antiTNF-a therapies (e.g. etanercept) has unveiled a spectrum of adverse effects, including infection [3] and a systemic lupus erythematosus (SLE)-like syndrome [4]. The latter appears to be biologically based on perturba...
متن کامل